By W. Creutzfeldt (auth.), Prof. Dr. med. Dr. h.c. W. Creutzfeldt (eds.)
New rules for the remedy of diabetes are defined during this quantity. specialists current experimental and scientific info on therapy with acarbose, an alpha-glucosidase inhibitor that delays absorption of quick carbohydrates. Toxicologic, pharmacologic and metabolic results of acarbose are mentioned. A concluding part at the destiny facets of alpha-glucosidase inhibition bargains a good overview of healing possibilities.
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Additional resources for Acarbose for the Treatment of Diabetes Mellitus
This dose dependency was been shown directly in early intestinal perfusion studies in man 44 B. Lembcke c: ·e 0 6,000 ...... x E 4,000 Glucose () -- 0 M 0 2,000 E ::1. c: ·e 0 ..... x 6,000 Sodium 4,000 E () 0 M -- 2,000 C" W ::1. c: ·e 0 ..... lg/ml acarbose .. 3. Dose-dependent effect of acarbose on the intestinal absorption of glucose from sucrose, and of concomitant sodium and water absorption in a 30-cm segment of jejunum. 005). [From Caspary and Kalisch (1978), with permission] (Caspary and Kalisch, 1978) (Fig.
V. administration [6-7]. 3% of the daily ingested dose of acarbose was excreted in urine. The fact that apparent plasma-acarbose concentrations, derived from radioactivity in plasma, were greatly in excess of unlabelled plasma-acarbose concentrations, The Disposition and Pharmacokinetics of Acarbose in Man 23 40 30 CD (I) e "0 20 .... e M 10 ---------------------------------- 0~~-------2~4----------~48~---------7~2--------~96 Time (h) Fig. 2. Cumulative urinary excretion of unlabelled acarbose (-----) and 14C-Iabelled acarbose plus metabolites ( - - - ) after ingestion of 200 mg/106 "Ci of 14C-acarbose at steady state.
7% ofthe orally administered dose is excreted as acarbose or "acarbose activity". 5% previously reported  but still negligible compared to the almost 90% after i. v. administration [6-7]. 3% of the daily ingested dose of acarbose was excreted in urine. The fact that apparent plasma-acarbose concentrations, derived from radioactivity in plasma, were greatly in excess of unlabelled plasma-acarbose concentrations, The Disposition and Pharmacokinetics of Acarbose in Man 23 40 30 CD (I) e "0 20 ....
Acarbose for the Treatment of Diabetes Mellitus by W. Creutzfeldt (auth.), Prof. Dr. med. Dr. h.c. W. Creutzfeldt (eds.)