By Mark H. Moss MD, Randy J. Horwitz MD, PhD, Robert F. Lemanske Jr. MD (auth.), Phil Lieberman MD, John A. Anderson MD (eds.)
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Additional info for Allergic Diseases: Diagnosis and Treatment
Most laboratories report lgE concentrations as international units (IU) or nanograms (ng) per milliliter. 4 ng lgE. LgiL) with two significant digits (XX x 10n). 4. Relationship of TotallgE to Allergic Disease Many studies have shown that total serum IgE concentrations are higher in allergic adults and children when compared to nonallergic individuals of similar ages. There is, however, a relatively large overlap between serum IgE concentrations in allergic and nonallergic individuals, limiting the diagnostic value of total IgE measurements.
10,000 AUJML CAT (IIAIIl): CAT (PELT) -10,000 BAUIMI EXTRACl'S ·BAYER, INC. BJSJ'AMINE ·CENTER LAB Fig. 2. Allergen testing. 24 Chapter 2 I Approach to the Allergic Patient 25 The most important ancillary test to confirm the diagnosis of allergy is the skin test, which is the "gold standard" in this regard. The skin test results must be interpreted in light of the history to determine the importance of a positive test. tests, based on size of the wheal and flare of a given test, is done in 15 min.
J Allergy Clin /mmunol1997;100:444-451. Williams PB, Dolen WK, Koepke JW, et al. Immunoassay of specific lgE: Use of a single point calibration curve in the modified radioallergosorbent test. Ann Allergy 1992;69:48-52. 4 Environmental Allergens Scott H Sicherer, MD and Peyton A. Eggleston, MD CoNTENTS INTRODUCTION OUTDOOR ALLERGENS INDOOR ALLERGENS SuGGESTED READING INTRODUCTION Allergens are low-molecular-weight proteins capable of inducing IgE antibody and triggering an allergic response. For those with an atopic predisposition, exposure to these environmental allergens causes not only the immunological sensitization required for the development of atopic disease but also the provocation of acute symptoms and the maintenance of chronic symptoms.
Allergic Diseases: Diagnosis and Treatment by Mark H. Moss MD, Randy J. Horwitz MD, PhD, Robert F. Lemanske Jr. MD (auth.), Phil Lieberman MD, John A. Anderson MD (eds.)